2. Signaling Pathways
  3. Immunology/Inflammation
  4. NOD-like Receptor (NLR)
  5. NOD-like Receptor (NLR) Isoform
  6. NOD-like Receptor (NLR) Agonist

NOD-like Receptor (NLR) Agonist

NOD-like Receptor (NLR) Agonists (10):

Cat. No. Product Name Effect Purity
  • HY-W158030
    2-Guanidinobezimidazole
    		Agonist
    2-Guanidinobezimidazole is a selective agonist of NLRP3, with a KD value of 1.29 μM to His-GFP-NLRP3. 2-Guanidinobezimidazole binds directly to the LRR domain of NLRP3, promoting inflammasome assembly and activation. 2-Guanidinobezimidazole promotes anti-tumor immunity, inhibits tumor growth, and overcome immune checkpoint blockade (ICB) resistance.
  • HY-156413
    NLRP3 agonist 1
    		Agonist 99.47%
    NLRP3 agonist 1 (compound 23) is a potent and orally active NLRP3 agonist. NLRP3 agonist 1 can activate the enzyme Caspase-1 to cleave pro-IL-1β and pro-IL-18 proinflammatory cytokines into their mature forms.
  • HY-P5544
    M-TriDAP
    		Agonist 98.64%
    M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) is a NOD1/2 agoist and biological active peptide.
  • HY-P5544A
    M-TriDAP TFA
    		Agonist
    M-TriDAP (N-Acetylmuramyl-L-Ala-γ-D-Glu-meso-diaminopimelic acid) TFA is a NOD1/2 agoist and biological active peptide.
  • HY-P5523A
    iE-DAP dihydrochloride
    		Agonist
    iE-DAP dihydrochloride is a Nod1 agonist. Nod1 recognition of iE-DAP dihydrochloride can activate the NF-κB pathway, leading to an inflammatory cytokine response. iE-DAP dihydrochloride can be used for the research of maternal-fetal inflammation and preterm labor.
  • HY-168137
    NOD2 agonist 2
    		Agonist
    NOD2 agonist 2 (compound 23) enhanced the antigen presentation of mouse bone marrow-derived dendritic cells (BMDCs), highlighting its potential as a vaccine adjuvant.
  • HY-P5523
    iE-DAP
    		Agonist
    iE-DAP is a Nod1 agonist. Nod1 recognition of iE-DAP can activate the NF-κB pathway, leading to an inflammatory cytokine response. iE-DAP can be used for the research of maternal-fetal inflammation and preterm labor.
  • HY-168136
    NOD2 agonist 1
    		Agonist
    NOD2 agonist 1 (compund 3) is a potent NOD2 agonist (EC50=4.6 nM).
  • HY-P5524
    C12-iE-DAP
    		Agonist
    C12-iE-DAP (Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid) is a biological active peptide. (a lauroyl (C12) group to the glutamic residue of iE-DAP , NOD1 agonist)
  • HY-156415
    NLRP3 agonist 2
    		Agonist
    NLRP3 agonist 2 (compound 22) is a orally active NLRP3 agonist.NLRP3 agonist 2 activates Caspase-1 in THP1 cells.